For adults with moderately to severely active ulcerative colitis (UC) who are corticosteroid dependent or have failed or were intolerant to conventional therapy
Injection Experience | SIMPONI® (golimumab)
SIMPONI® induction dosage regimen is two, 100-mg SC injections at Week 0, followed by 100 mg at Week 2, and then maintenance therapy with 100 mg every 4 weeks.
Humira® induction dosage regimen is four, 40-mg SC injections at Day 1 (given in one day or split over two consecutive days), followed by two, 40-mg SC injections at Day 15, and then maintenance therapy with 40 mg every other week starting at Day 29.
This is not intended to compare the safety, effectiveness, or uses of these treatments. Please refer to each product’s Prescribing Information for recommended dosing and administration. Humira® is a registered trademark of AbbVie Inc.
The SmartJect® autoinjector: designed to keep the needle out of sight
Patients will hear a first click when the dose begins to dispense and a second click when the injection is complete and the needle has retracted.
SIMPONI® is intended for use under the guidance and supervision of a physician. Patients may self-inject SIMPONI® after physician approval and proper training.
Prior to initiating SIMPONI® and periodically during therapy, patients should be evaluated for active tuberculosis and tested for latent infection. Prior to initiating SIMPONI®, patients should be tested for hepatitis B viral infection.
In the PURSUIT Induction study,
of SIMPONI®-treated patients (n=25/734) reported injection-site reactions vs 1.5% of placebo patients (n=5/330). Injection-site reactions included redness, swelling, itching, pain, bruising, and tingling.1,3Most common adverse reactions are upper respiratory tract infection, nasopharyngitis, and injection-site reactions
References: 1. SIMPONI® (golimumab) Prescribing Information. Janssen Biotech, Inc. 2. HUMIRA® (adalimumab) Prescribing Information. AbbVie Inc. 3. Sandborn WJ, Feagan BG, Marano C, et al; PURSUIT-SC Study Group. Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology. 2014;146:85-95.